Association of Minimal Clinically Important Difference With Infarct Volume in Clinical Poststroke Outcomes.

ABSTRACT:

Background

Infarct volume is an imaging biomarker of ischemic tissue injury strongly correlated with poststroke outcomes and reperfusion benefit. We aimed to evaluate the follow-up infarct volume (FIV) difference corresponding to a 1%, 5%, and 10% increase in probability of excellent functional outcomes after intravenous thrombolysis.

Methods

Data are from the AcT trial (Alteplase Compared to Tenecteplase in Patients With Acute Ischemic Stroke). Patients with 24-hour infarct volume segmentations were included. The primary outcome was excellent functional outcome (modified Rankin Scale score=0-1). Associations between outcomes and FIV were investigated with regression analyses adjusted for covariates. Sensitivity analyses examined patients with noncontrast computed tomography

SUBMITTER: Pensato U 

PROVIDER: S-EPMC12684630 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature