Study on the role and mechanism of magnesium-calcium-mineralized collagen composite scaffolds in the adjuvant treatment of cervical cancer.

ABSTRACT: One of the most prevalent malignant tumors in women is cervical cancer. Conventional chemoradiotherapy was frequently limited by significant side effects and acquired drug resistance. Consequently, there is an urgent need for high-performance biomaterials that effectively suppress tumor growth while exhibiting minimal off-target toxicity. Magnesium alloys represented a promising platform for anti-tumor applications due to their bioactive degradation products. This study developed novel magnesium alloy-mineralized collagen composite scaffolds and systematically evaluated their surface properties. Comprehensive in vitro and in vivo experimental models were used to elucidate the scaffolds' anti-tumor mechanisms. The results of this study demonstrated that magnesium alloy-mineral

SUBMITTER: Nie X 

PROVIDER: S-EPMC12684717 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature