Hybrid dielectric-graphene nanostructured SERS substrates for antibody sensing.

ABSTRACT: We present a hybrid surface-enhanced Raman spectroscopy (SERS) platform based on a nanostructured silicon substrate integrated with functionalized graphene for the selective detection of biomolecules such as prolactin and SARS-CoV-2 antibodies. The high-index substrate comprises an array of subwavelength silicon nanopillars that support Mie-type optical resonances, enabling strong electromagnetic field confinement with minimal heating and optical losses. Graphene monolayers are transferred onto the nanopillar array and functionalized using 1-pyrenebutanoic acid succinimidyl ester (PBASE), thus facilitating the selective immobilization of target antibodies via π-π interactions and covalent bonding. Graphene transfer, functionalization, and analyte binding are confirmed by the SERS en

SUBMITTER: Redolat J 

PROVIDER: S-EPMC12684743 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature