Dietary phospholipid carriers of DHA do not increase brain DHA levels: a replication study.

ABSTRACT: DHA is primarily found in fish and seafood as triacylglycerols and phospholipids (PLs). Oral administration of PL DHA forms, sn-1 lysophosphatidylcholine-DHA (sn-1 LPC-DHA) and di-DHA phosphatidylcholine (di-DHA-PC), has been suggested to increase brain DHA levels by ∼100% (relative percent) and up to ∼200% (concentration) compared with controls. In contrast, triacylglycerol-DHA and nonesterified-DHA do not produce increases in brain DHA when provided in the diet. However, a subsequent study using a higher dose of sn-1 LPC-DHA did not confirm these findings and reported no significant increase in brain DHA. To address these inconsistencies, we aimed to replicate previous investigations of PL-DHA forms (LPC and PC) and their impact on brain DHA levels. Mice were randomly divided into one of

SUBMITTER: Klievik BJ 

PROVIDER: S-EPMC12684751 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature