COVID-19 Vaccination and Cardiovascular Outcomes in Older Adults With Coronary Artery Disease and Heart Failure: Insights From a Large Propensity-Matched Cohort Study.

ABSTRACT:

Background

Patients with coronary artery disease or heart failure (HF) face heightened COVID-19 and cardiovascular risk, yet the long-term cardiac effects of COVID-19 vaccination in this population remain uncertain.

Methods

We performed a retrospective, propensity-matched cohort study using the TriNetX US Collaborative Network (December 2020-December 2022). Adults with coronary artery disease or HF were matched 1:1, creating 74 236 vaccinated and 74 236 calendar-aligned unvaccinated patients. Outcomes included mortality, acute myocardial infarction, stroke, HF hospitalization, deep vein thrombosis/pulmonary embolism, atrial fibrillation hospitalization, myocarditis, pericarditis, percutaneous coronary intervention, and coronary artery bypass grafting at 1-year and 2-year fol

SUBMITTER: Akbar UA 

PROVIDER: S-EPMC12684775 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature