Association of Non-Insulin-Based Insulin Resistance Indices With Risk of Incident Valvular Heart Disease: Results From the UK Biobank Cohort Study.

ABSTRACT:

Background

Non-insulin-based insulin resistance (IR) indices, including the estimated glucose disposal rate (eGDR), metabolic score for IR, and triglyceride-glucose indices (TyG-BMI, TyG-WC), have been implicated in cardiovascular diseases. However, few studies have investigated their associations with valvular heart disease (VHD).

Methods

We conducted a prospective cohort study of 354 265 eligible participants from the UK Biobank. The primary outcome was incident VHD, including aortic valve stenosis, mitral valve regurgitation, and aortic valve regurgitation. eGDR, metabolic score for IR, TyG-BMI, and TyG-WC were categorized into quartiles, with eGDR ranked inversely due to its negative correlation with IR. Multivariable Cox proportional hazards regression was used to asses

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12684784 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature