Molecular Mechanisms of Exosomes From Human iPSC-Cardiomyocytes and Mesenchymal Stem Cells in Restoring the Injured Myocardium.

ABSTRACT:

Background

Exosomes are extracellular vesicles 30 to 150 nm in size, mediating the paracrine effects of mesenchymal stem cells (MSCs) and induced pluripotent stem cell-derived cardiomyocytes (iCMs) when used to restore the injured myocardium. While both MSC- and iCM-derived exosomes (MSC-Exo, iCM-Exo) improve cardiac function, their mechanisms of action remain incompletely understood. This study investigates the shared and distinct effects of iCM-Exo and MSC-Exo in a porcine ischemia-reperfusion injury model.

Methods

Female Yorkshire swine underwent proximal left anterior descending artery occlusion with a catheter balloon to induce ischemia-reperfusion injury. Ten 500-μL transendocardial injections delivered a total of 5×10¹¹ iCM-Exo or MSC-Exo into the peri-infa

SUBMITTER: Tzng E 

PROVIDER: S-EPMC12684797 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature