Inflammation and Cognitive Decline: A Population-Based Cohort Study Among Aging Adults With Atrial Fibrillation.

ABSTRACT:

Background

Despite associations between atrial fibrillation (AF) and cognitive decline independent of stroke, pathways underlying this relationship remain unclear. Inflammatory markers, such as CRP (C-reactive protein), are associated with blood-brain barrier (BBB) permeability, potentially leading to neuroinflammation and neurodegeneration. We estimated associations of CRP with cognitive impairment and death in aging adults with AF.

Methods

Adults aged ≥45 years with prevalent AF and no cognitive impairment were identified from the REGARDS (Reasons for Geographic and Racial Differences in Stroke) cohort (N=30 239). Plasma CRP was measured at baseline and cognitive status measured annually using the Six-Item Screener. Competing risks Cox proportional hazards regression was u

SUBMITTER: Marion D 

PROVIDER: S-EPMC12684798 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature