Admixture Mapping of Lipid Traits in Hispanic Americans.

ABSTRACT:

Background

Admixture mapping can be leveraged to identify genomic loci associated with disease traits in admixed individuals such as Hispanic Americans.

Methods and results

We characterized fine-scale population structure of participants (n=105 108) in the multiethnic eMERGE-III (electronic Medical Records and Genomics) cohort, using reference panels from the 1000 Genomes Project and a Native American cohort. We defined "genetically admixed Hispanic Americans" as those having ≥10% Native American genetic ancestry (n=5025), in addition to European (specifically, Iberian) and African genetic ancestry. This population descriptor was subsequently applied to 3 other cohorts: the MESA (Multi-Ethnic Study of Atherosclerosis; n=1176), WHI (Women's Health Initiative; n=2873), and the

SUBMITTER: Ding K 

PROVIDER: S-EPMC12684806 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature