Imputation of ancient canid genomes reveals inbreeding history over the past 10,000 years.

ABSTRACT: The multi-millennia-long history between dogs and humans has placed them at the forefront of archaeological and genomic research. Despite ongoing efforts including the analysis of ancient dog and wolf genomes, many questions remain regarding the evolutionary processes that led to the diversity of breeds today. Although ancient genome sequences provide valuable information about these processes, their utility is hindered by low depths of coverage and postmortem damage, which inhibits confident genotype calling. In the present study, we assess how genotype imputation of ancient dog and wolf genomes, using a large reference panel, can increase the amount of information provided by ancient datasets. We evaluated imputation accuracy by down-sampling high-coverage dog and wolf genomes to 0.05 to

SUBMITTER: Bougiouri K 

PROVIDER: S-EPMC12684900 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature