NRIR promotes immune escape in hepatocellular cancer by regulating IFNγ-induced PD-L1 expression.

ABSTRACT:

Introduction

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide, with insensitive treatment and poor prognosis; in recent years, breakthroughs in IFN signaling pathway and PDL1/PD1 signaling pathway in HCC immunotherapy research.

Objectives

This study aimed to investigate the molecular mechanisms controlling the immune response and immune evasion.

Methods

NRIR was identified as a differential gene affecting the IFN signaling pathway and PDL1/PD1 signaling pathway in HCC by bioinformatics, and the function of NRIR was investigated in the HCC cell model and the xenograft mouse model. Quantitative Real-time PCR (qRT-PCR) was used to detect NRIR and PD-L1 mRNAs in hepatocellular carcinoma tissues, and dual luciferase reporter gene assay, f

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12684935 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature