Dual function of MrgprB2 receptor-dependent neural immune axis in chronic pain.

ABSTRACT:

Introduction

Neuro-immune interactions have been recognized to be involved in the development of neuropathic pain induced by chemotherapeutic drugs (CINP). However, its role in pain resolution remains largely unknown, particularly concerning mast cells.

Objectives

To investigate the bidirectional modulation of mast cell Mas-related G protein-coupled receptor B2 (MrgprB2)-mediated neuro-immune interactions in CINP.

Methods

CINP model was established in wild-type mice, Mas-related G protein-coupled receptor D knockout (MrgprD^-/-) mice, mast cell-deficient mice, MrgprB2 knockout (MrgprB2^-/-) mice, and MrgprB2-Cre tdTomato mice. The role of MrgprB2 receptor in CINP was investigated by calcium imaging, cytokine antibody arrays, mining of single-cell s

SUBMITTER: Jiang Y 

PROVIDER: S-EPMC12684944 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature