Neonatal sevoflurane exposures inhibits DHHC5-mediated palmitoylation of TfR1 in oligodendrocytes, leading to hypomyelination and neurological impairments.

ABSTRACT:

Introduction

Neonatal anesthesia-related neurological impairments are of significant concern, closely linked to oligodendrocyte dysfunction. However, there is a notable temporal discrepancy between the sustained development of oligodendrocytes (myelination) and the short-term vulnerability to anesthesia exposures.

Objectives

Given the significant rise in iron demand by oligodendrocytes during neonatal period, our objective was to clarify the potential roles and underlying mechanisms of iron homeostasis, particularly focusing on transferrin receptor 1 (TfR1), in governing the transient susceptibility to anesthesia.

Methods

Sevoflurane (3 %, 2 h/day) was administered to wildtype or Pdgfrα-Cre^ERT mice from postnatal day (P)6 to P8. Subsequently, behavioral tes

SUBMITTER: Liu H 

PROVIDER: S-EPMC12684956 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature