Advances in the pathology and treatment of osteoarthritis.

ABSTRACT:

Background

Osteoarthritis (OA), a widespread degenerative joint disease, predominantly affects individuals from middle age onwards, exhibiting non-inflammatory characteristics. OA leads to the gradual deterioration of articular cartilage and subchondral bone, causing pain and reduced mobility. The risk of OA increases with age, making it a critical health concern for seniors. Despite significant research efforts and various therapeutic approaches, the precise causes of OA remain unclear.

Aim of review

This paper provides a thorough examination of OA characteristics, pathogenic mechanisms at various levels, and personalized treatment strategies for different OA stages. The review aims to enhance understanding of disease mechanisms and establish a theoretical framework for dev

SUBMITTER: Peng X 

PROVIDER: S-EPMC12684957 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature