Small siphophage binding to an open state of the LptDE outer membrane lipopolysaccharide translocon.

ABSTRACT: Bacteriophages are bacterial viruses that provide alternatives to small-molecule drugs to combat infections by antibiotic-resistant bacteria. To infect a bacterial host, a phage needs to bind to the bacterial surface via receptor binding proteins (RBPs), which are critical for determining host specificity. For functionally important receptors, the RBP-receptor interaction could be exploited via phage steering, where emerging bacterial resistance due to receptor modification could make bacteria less fit or virulent. Despite this, relatively little is known about RBP-receptor interactions. Here, we build on the recent discovery of coliphages that have the outer membrane (OM) lipopolysaccharide translocon LptDE as their terminal receptor and show via cryogenic electron microscopy that, surpri

SUBMITTER: Dunbar E 

PROVIDER: S-EPMC12685063 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature