Prefrontal and ventral striatal neural correlates of reversal learning in anorexia nervosa and bulimia nervosa.

ABSTRACT: Difficulty with reversal learning (RL)-appropriately shifting behavior following outcome contingency changes-may represent a shared or distinct mechanism across eating disorder (ED) diagnoses. We tested whether RL-related neural correlates differ among adults without and with EDs (anorexia nervosa, restricting subtype [AN-R], AN binge-eating/purging subtype [AN-BP], and bulimia nervosa [BN]) and whether these correlates correspond to ED-symptom severity and frequency. We hypothesized that individuals with EDs would demonstrate differential neural activation during RL relative to individuals without, that activation would differentiate AN-BP and BN versus AN-R, and that activation would predict ED-severity metrics. Medically stable participants with AN-R (n = 22), AN-BP (n = 20), and BN (n 

SUBMITTER: Murray MF 

PROVIDER: S-EPMC12685067 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature