Cytomegalovirus disrupts Lamin A/C to control microtubule-mediated nuclear movement and cell migration.

ABSTRACT: Human cytomegalovirus (HCMV) disrupts the inner nuclear Lamin A/C meshwork to facilitate virion egress. Here, we show that targeting Lamin A/C also plays a previously unrecognized role in HCMV-induced rewiring of cytoskeletal connections that control nuclear movement and cell migration at later stages of infection. Specifically, HCMV was found to employ distinct strategies to downregulate Lamin A/C and SUN2, which together regulate linker of nucleoskeleton and cytoskeleton (LINC) complexes that most often connect the nuclear membrane with cytoplasmic actin filaments. Unexpectedly, inhibition of the viral kinase, pUL97, or expression of nonphosphorylatable mutants of Lamin A/C failed to restore SUN2 expression or significant actin filament assembly. Moreover, exogenous reexpression of SUN2

SUBMITTER: Mahmud J 

PROVIDER: S-EPMC12685118 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature