Large-scale seroepidemiology uncovers nephro-urological pathologies in people with tau autoimmunity.

ABSTRACT: Intraneuronal aggregates of the microtubule-associated protein tau play a pivotal role in Alzheimer's disease and several other neurodegenerative syndromes. Anti-tau antibodies can reduce pathology in mouse models of neurodegeneration and are currently being tested in humans. Here, we performed a large-scale seroepidemiological search for anti-tau IgG autoantibodies (ατ) on 40,497 human plasma samples. High-titer ατ+ individuals were surprisingly prevalent, with hospital patients being three times more likely to be ατ+ (EC50 ≥ 26; a nominal dilution of >1/64) than healthy blood donors (4.8% versus 1.6%). The prevalence increased with age over 70 years-old (RR 1.26, 95% CI 1.11-1.43, P < 0.001) and was higher for women (RR 1.20, 95% CI 1.07-1.39, P = 0.002). The autoantibodies bound selecti

SUBMITTER: Magalhaes AD 

PROVIDER: S-EPMC12685212 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature