Longitudinal biomarker progression and validation for predicting operational tolerance in a prospective multicenter liver transplantation immunosuppression withdrawal trial.

ABSTRACT: Liver transplantation (LT) is a life-saving treatment for end-stage liver disease, but long-term immunosuppression (IS) is associated with significant side effects. Achieving operational tolerance (OT), where the graft is accepted without IS, remains a critical goal. Biomarkers play a pivotal role in understanding the complex mechanisms of OT, enabling personalized treatment strategies and improving patient outcomes. Additionally, machine learning techniques offer powerful tools for identifying predictive biomarkers and optimizing IS withdrawal protocols. This multicenter trial aimed to investigate the longitudinal evolution of genetic biomarkers during IS withdrawal and validate their predictive value for OT in LT recipients. A prospective, multicenter IS withdrawal trial was conducted wi

SUBMITTER: Lopez-Diaz G 

PROVIDER: S-EPMC12685220 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature