Lactate dehydrogenase is an indicator for outcomes of short-term and long-term in septic patients.

ABSTRACT:

Objective

The association between lactate dehydrogenase (LDH) and clinical outcomes in sepsis was explored based on MIMIC-IV database.

Methods

This was a retrospective study. Models including unadjusted model and adjusted models were performed for exploring the association of LDH with 30-day mortality and 1-year mortality. The smooth fitting curves were constructed by using generalized additive model. The predictive value of LDH for clinical outcomes in sepsis was evaluated. The statistical software of EmpowerStats (http://www. empowerstats. com) and R (http://www.R-project.org) were applied for analysis.

Results

6775 sepsis patients were included. After adjusted for all potential confounders, for every 100 IU/L increment in LDH, the risk of 30-day mortality and 1-yea

SUBMITTER: Zeng Z 

PROVIDER: S-EPMC12685224 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature