Entorhinal Silencing Reveals Energy Cascade Organization of Hippocampal Oscillations.

ABSTRACT: Hippocampal theta and gamma rhythms are often viewed as discrete channels supporting distinct cognitive operations. In particular, "gamma multiplexing" models propose that slow and fast gamma bands independently encode separate information streams or memory processes. Here, we present an alternative view: hippocampal oscillations form an interdependent process, governed by an energy cascade akin to turbulent flow across scales. In this framework, large-amplitude, low-frequency rhythms drive energy transfer to higher-frequency oscillations, rather than acting as isolated carriers of segregated information. Using laminar local field potential recordings in freely moving mice, we show that optogenetic inactivation of the medial entorhinal cortex or CA1 reduces theta power, leading to proporti

SUBMITTER: Zhao B 

PROVIDER: S-EPMC12685368 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature