Association Between Migraine and Frailty Among Middle-Aged and Older Adults: A Cross-Sectional Study Based on CHARLS.

ABSTRACT:

Background

Frailty represents a geriatric syndrome characterized by diminished physiological reserves and increased vulnerability to adverse health outcomes. While chronic diseases are established frailty risk factors, the relationship between migraine-a prevalent neurological condition affecting millions globally-and frailty development remains unexplored, representing a critical knowledge gap in geriatric neurology.

Methods

We conducted a cross-sectional analysis using baseline data (2011-2015) from the China Health and Retirement Longitudinal Study (CHARLS), a nationally representative cohort. Frailty was assessed using a validated 32-item Frailty Index based on deficit accumulation theory. Multivariable logistic regression models examined migraine-frailty associations, w

SUBMITTER: Rui S 

PROVIDER: S-EPMC12685432 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature