Minimal important change of the knee injury and osteoarthritis outcome score in patients with mild to moderate knee osteoarthritis - using three different anchor-based methods.

ABSTRACT:

Objective

To estimate Minimal Important Change (MIC) for improvement in the Knee injury and Osteoarthritis Outcome Score (KOOS) in patients with mild to moderate knee osteoarthritis (OA), using three recommended anchor-based methods, and examine how methodological choices influence these estimates.

Design

Secondary analysis of a three-arm randomized controlled trial. KOOS and a Global Rating of Change (GROC) scale were collected at baseline and 4-month follow-up. MIC values were estimated using predictive modeling, Mean Change, and Receiver Operating Characteristic (ROC) methods. Sensitivity analyses assessed the impact of different anchor cut-offs.

Results

Data were available for 131 patients undergoing non-surgical treatment (mean age 57.4 years, 50 ​% female). At f

SUBMITTER: Lundquist HK 

PROVIDER: S-EPMC12685517 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature