The ubiquitin-binding protein ANKRD13A mediates VCP-dependent mitochondrial outer membrane rupture during PINK1/Parkin-mediated mitophagy.

ABSTRACT: PINK1/Parkin-mediated mitophagy is a major homeostatic mechanism by which cells selectively remove damaged, depolarized mitochondria. A signature event in this form of mitophagy is the rupture of the mitochondrial outer membrane (OMM), a process required for proper disposal of mitochondria. The OMM rupture results in the topological exposure of the mitochondrial inner membrane (IMM) mitophagy receptors, which are recognized by autophagy machinery, thus promoting the turnover of the depolarized mitochondria. However, due to the lack of efficient tools to measure OMM rupture, our mechanistic understanding of this process has been limited. In this study, we identified ankyrin repeat domain-containing protein 13 A (ANKRD13A) as a novel mitophagy factor that interacts with multiple mitochondria

SUBMITTER: Chu WH 

PROVIDER: S-EPMC12685520 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature