Endogenous mitochondrial hydrogen peroxide regulates neurogenesis during cortical development.

ABSTRACT: Reactive oxygen species (ROS), particularly superoxide anion (O₂^•-) and hydrogen peroxide (H₂O₂), originating from mitochondria, are increasingly recognized as critical mediators of physiological signaling and cellular function. While in the adult brain, mitochondrial ROS, specifically mitochondrial H₂O₂, modulate metabolism and sustains cognitive processes, their role in the developing cerebral cortex remains undefined. Here, we leverage a knock-in mouse model constitutively expressing mitochondrially targeted catalase (mCAT) to attenuate mitochondrial H₂O₂ levels and investigate their impact during cortical development. In neurosphere cultures derived from embryonic day 14.5 (E14.5) mCAT mice, reduced

SUBMITTER: Mengual R 

PROVIDER: S-EPMC12685554 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature