Antivirulence Activity and Therapeutic Potential of Jumbo <i>Vibrio</i> Phage pVa-22 against <i>Vibrio alginolyticus</i>.

ABSTRACT: Vibrio alginolyticus is an emerging zoonotic pathogen responsible for severe aquaculture and human infections, and its increasing antimicrobial resistance calls for alternative control strategies. Here, we report the isolation and characterization of the jumbo phage pVa-22, a phiKZ-like phage that infects V. alginolyticus. Morphological analysis of the phage via transmission electron microscopy revealed a large icosahedral capsid and contractile tail consistent with jumbo vibriophages. pVa-22 exhibited notable stability across broad range of temperature (4-37°C) and pH values (3-11), as well as rapid adsorption and a moderate burst-size and latent period. Host range assays revealed strong lytic activity against Vibrio species associated with foodborne illness, including V.

SUBMITTER: Jo SJ 

PROVIDER: S-EPMC12685585 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature