Circulating NET Biomarkers as Predictors of Inflammatory Storm Escalation and Critical Illness in COVID-19.

ABSTRACT: COVID-19 demonstrates distinct clinical heterogeneity, ranging from mild symptoms to severe acute respiratory distress syndrome (ARDS). Neutrophil extracellular traps (NETs), which are web-like structures consisting of decondensed DNA adorned with cytotoxic proteins such as myeloperoxidase (MPO) and citrullinated histone H3 (CitH3), play a crucial role in pathogen containment. However, they may also promote immunothrombosis and tissue injury. This research aimed to explore the association between NET formation and the severity of COVID-19. Plasma samples were collected from 99 patients diagnosed between 2022 and 2023. NET remnants were quantified through cell-free DNA (cfDNA), MPO-DNA, neutrophil elastase (NE)-DNA complexes, histone-DNA complexes, and CitH3. The levels of all NET biomarker

SUBMITTER: Liu W 

PROVIDER: S-EPMC12685590 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature