Association of thyroid autoimmunity and pregnancy outcomes in unexplained recurrent pregnancy loss women: a prospective cohort study.

ABSTRACT:

Background

Unexplained recurrent pregnancy loss (URPL) and thyroid autoimmunity (TAI) have received considerable attention. However, the association between TAI and subsequent infertility or pregnancy outcomes among euthyroid women with URPL remains unclear. This study aimed to clarify these relationships.

Methods

From September 2019 to December 2022, we prospectively enrolled women with URPL at the Lanzhou University Second Hospital and collected pre-pregnancy and first-trimester data. Participants were divided into two groups: TAI and non-TAI, based on their thyroid antibody status. Changes in thyroid function parameters from pre-pregnancy to the first trimester were compared between the two groups. We assessed the incidence of infertility, subsequent pregnancy loss, and p

SUBMITTER: Wang R 

PROVIDER: S-EPMC12685602 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature