Integrative GWAS and Mendelian Randomization Analysis Identifies IREB2 and CD27+ Memory B Cells as Core Drivers of COPD to Lung Cancer Progression.

ABSTRACT: Chronic obstructive pulmonary disease (COPD) associates with increased lung cancer incidence and shares genetic susceptibility, yet its independent causal role and driver mechanisms are poorly understood. We integrated data from the National Health and Nutrition Examination Survey (NHANES) cohort with genome-wide association studies (GWAS) summary statistics and Mendelian randomization analyses to map genetic correlations and infer causality between COPD phenotypes and lung cancer. Post-GWAS methods-including transcriptome-wide association study, colocalization, partitioned heritability via heritability estimation from summary statistics (ρ-HESS), and cross-phenotype association (CPASSOC)-identified shared susceptibility loci, highlighting IREB2 and CD27⁺ B cells as potential mediators. El

SUBMITTER: Yi E 

PROVIDER: S-EPMC12685611 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature