Subacute edema progression after acute ischemic stroke: impact of intravenous alteplase administration and reperfusion degree.

ABSTRACT:

Introduction

Alteplase is known to increase the risk of blood-brain barrier integrity disruption, potentiating hemorrhage and edema. Evolving edema reduces chances of good functional outcomes. There is a paucity of studies that investigate the role of alteplase administration in subacute edema progression. Here we aim to associate alteplase administration in combination with the degree of reperfusion on edema, measured by net water uptake.

Methods

We included 115 patients from the MRCLEAN NO-IV trial with baseline, 24-h and 1-week follow-up non-contrast CT scans. The cohort consisted of patients who received intravenous thrombolysis (IVT)+ endovascular treatment (EVT) vs. EVT alone. Net water uptake (NWU) was calculated as a ratio of mean lesion density compared to its homol

SUBMITTER: Olszewski W 

PROVIDER: S-EPMC12685625 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature