Independent component analysis of resting-state fMRI identifies regions associated with seizure freedom after laser interstitial thermal therapy for temporal lobe epilepsy.

ABSTRACT:

Objective

Temporal lobe epilepsy (TLE) is a common form of drug-resistant epilepsy often treated with surgical interventions, including laser interstitial thermal therapy (LITT). However, patient-specific factors influencing LITT outcomes remain unclear. This retrospective study aimed to identify pre-operative resting-state functional MRI (rs-fMRI) patterns associated with seizure freedom following LITT in mesial TLE.

Methods

We analyzed rs-fMRI data from 28 patients with mesial TLE who underwent LITT, classifying them into seizure-free (SF) and not seizure-free (NSF) groups based on 12-month post-operative outcomes. Independent component analysis (ICA) was used to identify subject-specific brain networks, and generalized linear models (GLM) were employed to assess associati

SUBMITTER: Alizadeh M 

PROVIDER: S-EPMC12685642 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature