APOL1 is a novel prognostic biomarker in thyroid cancer and correlates with immune infiltration.

ABSTRACT:

Background

Although apolipoprotein 1 (APOL1) expression is upregulated in several types of cancers, including thyroid cancer (THCA), its specific role in THCA remains unclear. The aim of the present study was to analyze whether APOL1 could serve as a prognostic marker and predictor of immune cell infiltration (ICI) in THCA.

Methods

APOL1 expression was assessed using TCGA and GTEx data, based on data from The Cancer Genome Atlas (TCGA). The diagnostic and prognostic value of APOL1 was assessed using Kaplan-Meier survival curves, receiver operating characteristic curves, Cox regression analysis and enrichment analysis in R. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology were used to determine APOL1-related pathways. Furthermore, the correlation between APOL1 expres

SUBMITTER: Man J 

PROVIDER: S-EPMC12685650 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature