Clinical correlates of perfusion and diffusion MRI metrics in cognitively unimpaired older adults.

ABSTRACT: Cerebral small vessel disease (CSVD) is associated with vascular risk factors (VRFs) and early executive function (EF) decline. Because periventricular white matter (PVWM) is the most weakly perfused brain region, it may be particularly sensitive to early manifestations of CSVD. Among 101 cognitively unimpaired adults, we assessed the cross-sectional correlations of arterial spin-labeled derived absolute and relative cerebral blood flow (CBF and rCBF, respectively) and diffusion tensor imaging (DTI) metrics in normal-appearing WM (NA-WM) and normal-appearing PVWM (NA-PVWM) with VRFs and EF, and evaluated the mediation and moderation relationships between these variables in amyloid β negative (Aβ-) subjects. CBF, rCBF, and DTI metrics were significantly different in NA-PVWM compared to NA-W

SUBMITTER: Shakibajahromi B 

PROVIDER: S-EPMC12685692 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature