Fatty infiltration and cross-sectional area as indicators of muscle mass in osteoporosis: a meta-regression study.

ABSTRACT:

Background

Paraspinal muscle morphology, including cross-sectional area (CSA) and fatty infiltration (FI), has been increasingly recognized as a potential imaging-based indicator of osteoporosis. However, the extent to which these muscle parameters differ across osteoporosis, osteopenia, and healthy populations remains unclear.

Methods

A systematic meta-analysis was conducted based on 14 studies published from inception to January 25, 2025, comprising 125 effect size estimates related to CSA and FI across key paraspinal muscles. Pooled standardized mean differences (SMDs) were calculated using a random-effects model. Subgroup analyses were stratified by muscle group and diagnostic comparison. Three-level meta-regression models were implemented to examine the influence of stu

SUBMITTER: Sun G 

PROVIDER: S-EPMC12685714 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature