A retrospective cohort study on the differential overall survival rates between surgical intervention and chemotherapy in stage IV pancreatic cancer patients.

ABSTRACT:

Background

Patients with pancreatic cancer and liver metastases (PCLM) are typically deemed ineligible for curative surgery, with chemotherapy being the standard care. However, surgical resection may benefit select patients. This study investigated whether integrating surgery with chemotherapy improves overall survival (OS) compared to chemotherapy alone in PCLM.

Methods

We conducted a retrospective cohort study of 24,802 patients with stage IV pancreatic cancer from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) program (2010-2021). A 1:4 propensity score matching (PSM) was applied to balance 15 baseline covariates. Survival differences between groups were assessed via Kaplan-Meier and multivariate Cox analyses.

Results

A total of

SUBMITTER: Shao S 

PROVIDER: S-EPMC12685772 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature