Identifying risk factors for poor prognosis and developing prognostic model in patients achieving pathological complete response after neoadjuvant therapy for breast cancer.

ABSTRACT:

Background

A subset of breast cancer patients who achieved pathological complete response (pCR) after neoadjuvant therapy (NAT) still experience poor outcomes, including recurrence, metastasis, and death. This study aims to identify risk factors for adverse outcomes in pCR patients, construct predictive models, elucidate molecular subtype-specific prognostic determinants, and explore the peaks of death and progression events among different subtypes.

Methods

Female patients who received NAT and achieved pCR in the Surveillance, Epidemiology, and End Results (SEER) database were enrolled in this research. This study aims to clarify independent prognostic factors of overall survival (OS) and event-free survival (EFS) by using Cox regression analyses as well as developing nomog

SUBMITTER: Lin X 

PROVIDER: S-EPMC12685783 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature