Association between SQSTM1 dysregulation and risk in alopecia areata: a Mendelian randomization study.

ABSTRACT:

Background

Alopecia areata (AA) is an autoimmune disease typified by nonscarring hair loss. It manifests as a heterogeneous disorder with diverse clinical presentations and variable treatment responses, underscoring the significance of identifying novel biomarkers for precision management.

Objective

This study aims to explore the relationship between metabolic reprogramming-related genes (MRRGs) and the risk of developing AA.

Methods

MRRGs were identified through the GeneCards database and existing literature. Genetic instruments were obtained from the eQTLGen database, and AA-related data were retrieved from the OpenGWAS database. The TwoSampleMR R package was applied for statistical analysis. Additionally, RT-qPCR and immunofluorescence assays were performed to vali

SUBMITTER: Hu L 

PROVIDER: S-EPMC12685797 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature