Gut microbiota alterations and systemic inflammation in community-acquired pneumonia: a prospective gut-lung axis study.

ABSTRACT: Up to now, only a few scattered studies have provided some evidence for the relationship between gut microbiota and community-acquired pneumonia (CAP), and the mechanisms by which gut microbiota contributes to the occurrence and development of CAP via the gut-lung axis require further investigation. In this study, fecal and serum samples from CAP patients and healthy controls were analyzed using 16S rRNA gene sequencing and enzyme-linked immunosorbent assay. The results showed that compared with healthy controls, alpha-diversity of gut microbiota in CAP patients was significantly reduced, and beta-diversity was significantly different at operational taxonomic units (OTUs), class, order, family, genus, and species levels. The abundance of short-chain fatty acid-producing genera in CAP patie

SUBMITTER: Yang XQ 

PROVIDER: S-EPMC12685802 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature