Population pharmacokinetics/pharmacodynamics and safety of YPEG-rhGH in elderly subjects.

ABSTRACT: Y-shape branched PEGylated recombinant human growth hormone (YPEG-rhGH) is a suitable drug for the treatment of growth hormone deficiency. The aim of this study was to establish a population pharmacokinetics/pharmacodynamics (PopPK/PD) model of YPEG-rhGH in the elderly. The safety and tolerability of the drug were investigated, and the possibility of flexible dosing regimen was explored. A total of 16 healthy elderly subjects and 36 healthy adults participated in the PopPK analysis. Only elderly subjects were included in the PopPK/PD analysis. After subcutaneous injection of the drug, serum samples were collected to analyze the time course of YPEG-rhGH concentrations and insulin-like growth factor-1 (IGF-1) levels. Additionally, the safety and tolerability of the investigational drug were

SUBMITTER: He Y 

PROVIDER: S-EPMC12685806 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature