Impact of delayed cord clamping on mesenchymal, hemopoietic progenitor, and immune cells in very preterm neonates.

ABSTRACT:

Objective

We aimed to investigate the impact of delayed cord clamping (DCC) on the levels of blood mesenchymal (MSCs), hemopoietic progenitor (HPCs), and immune cells in very preterm neonates.

Methods

We prospectively examined 21 neonates with a median gestational age of 32 weeks (interquartile range, IQR 29-32) who had DCC, and 19 neonates with a median gestational age of 31 weeks (IQR 30-32) who had immediate cord clamping (ICC). We measured the levels of MSCs, HPCs, very small embryonic-like stem cells (VSELs), early endothelial progenitor cells (EPCs), late EPCs, and the immunophenotype in the first, 10th, and 30th day of life, and associated them with late-onset sepsis and bronchopulmonary dysplasia (BPD).

Results

DCC-neonates compared to ICC-neonates had signifi

SUBMITTER: Drogouti E 

PROVIDER: S-EPMC12685807 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature