Knowledge, attitudes, and practices toward linezolid-serotonergic drug interactions: a cross-sectional study.

ABSTRACT:

Background

Concomitant use of linezolid with serotonergic agents may lead to serotonin syndrome, a rare but serious complication. This study assessed healthcare providers' knowledge, attitudes, and practices (KAP) to identify gaps and inform strategies to enhance patient safety.

Methods

We conducted a nationwide, cross-sectional survey among physicians, pharmacists, and nurses practicing in Saudi Arabia. Participants completed a validated questionnaire designed to assess KAP related to linezolid-serotonergic drug interactions. KAP scores were categorized and analyzed using logistic regression to identify predictors associated with higher performance.

Results

Among 116 respondents, 69.0% reported awareness of linezolid-serotonergic drug interaction. However, only 30.2%

SUBMITTER: Aldairem A 

PROVIDER: S-EPMC12685812 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature