IgA expressed by glomerular mesangial cells is involved in the pathogenesis of IgA nephropathy.

ABSTRACT:

Background

The widely accepted "multi-hit hypothesis" of IgAN pathogenesis was challenged, as efficient depletion of CD20+ B cells failed to reduce serum galactose-deficient IgA1 (Gd-IgA1) or proteinuria in IgAN patients. Our group has discovered glomerular mesangial cells (GMCs) as another source of IgA, while immunoglobulin produced by non-B cells (non-B Ig) participating in several inflammatory and neoplastic diseases arose as a new concept in immunology. It is still unclear whether IgA produced by GMCs participates in the pathogenesis of IgAN and what its preliminary mechanism is.

Methods

The transcription of IGHA1 and its associated function in GMCs were demonstrated by single-cell RNA sequencing (scRNA-seq) analysis. IGHA1 transcription in glomerular mesa

SUBMITTER: Zhang H 

PROVIDER: S-EPMC12685827 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature