Development of a standardized ovine aortic stenosis model: a pathomimetic platform for TAVI evaluation and durability testing.

ABSTRACT:

Background

Transcatheter aortic valve implantation (TAVI) has gained widespread clinical acceptance owing to its minimally invasive approach and enhanced postoperative recovery. This study developed a standardized ovine aortic stenosis (AS) model through surgical implantation of a circular bioengineered annular stent in the aortic root, creating a reproducible pathomimetic platform for TAVI evaluation. Following hemodynamic stabilization, TAVI procedures were performed to systematically assess mid-to-long-term valve functionality and calcification progression.

Methods

AS model was established in 11 sheep using extracorporeal circulation assistance technology. Following hemodynamic stabilization (2-4 weeks), TAVI was performed. The modeled sheep were divided into two groups t

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC12685841 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature