Beyond prescriptions: chronic medication adherence predicts mortality risk in a large-scale cohort study.

ABSTRACT:

Objectives

The Medication Adherence Risk Score (MARS) is a calculated score using pharmacy transactional data spanning 50% of the South African private pharmacy market. This study aims to demonstrate that the existing MARS model enhances risk stratification by identifying individuals at increased risk of mortality related to non-adherence to chronic medication.

Methods

This was a retrospective cohort study in which an analysis of the relative mortality experience was compared to a standard fully underwritten base was performed for each of the MARS categories (low, medium, high and very high). The actual-to-expected ratio (AER) and relative risk (RR) for each category were compared across age groups and gender. The least absolute shrinkage and selection operator (LASSO) regre

SUBMITTER: Hamuy Blanco J 

PROVIDER: S-EPMC12685934 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature