Neuropsychiatric SLE in children with childhood-onset lupus nephritis: a 20-year retrospective cohort study.

ABSTRACT:

Background

Neuropsychiatric systemic lupus erythematosus (NPSLE) and lupus nephritis (LN) are two major, life-threatening complications in childhood-onset SLE (cSLE). Data regarding the epidemiology and prognosis of children with concurrent NPSLE and LN remain scarce. This study aimed to investigate the clinical characteristics, associated factors, and outcomes of NPSLE in Chinese children with LN.

Methods

A retrospective cohort study was conducted at the Paediatric Nephrology Centre of Hong Kong Children's Hospital, including 95 Chinese children with biopsy-proven cLN. Comparisons were made between children with and without NPSLE.

Results

Of 95 Chinese children with cLN, 11 (12%) developed NPSLE, and 31 NPSLE events were reported. Estimated glomerular filtration rate

SUBMITTER: Wong ML 

PROVIDER: S-EPMC12685967 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature