Early fluid status and severe intraventricular hemorrhage or death in extremely preterm infants.

ABSTRACT:

Background

Measures of early postnatal fluid balance may be associated with severe intraventricular hemorrhage (sIVH) and/or death in extremely preterm infants in the first postnatal week.

Methods

A single-center, retrospective cohort study including actively treated inborn infants weighing ≥ 400 g and 22-27 weeks' gestation from 2014-2021. Longitudinal mixed effect models compared daily fluid balance covariates including serum sodium, percent weight change, total fluid intake, urine output, and fluid balance (daily weight - birth weight /birth weight × 100) among infants with and without sIVH or death, during the first seven postnatal days. Multiple regression and machine learning models were developed to predict sIVH and/or death. Variables that were incorporated into the

SUBMITTER: Weaver LJ 

PROVIDER: S-EPMC12685979 | biostudies-literature | 2026 Dec

REPOSITORIES: biostudies-literature