DNA methylation of genes involved in lipid metabolism drives adiponectin levels and metabolic disease.

ABSTRACT:

Aims/hypothesis

Despite playing critical roles in the pathophysiology of type 2 diabetes and other metabolic disorders, the molecular mechanisms underlying circulating adipokine levels remain poorly understood. By identifying genomic regions involved in the regulation of adipokine levels and adipokine-mediated disease risk, we can improve our understanding of type 2 diabetes pathogenesis and inter-individual differences in metabolic risk.

Methods

We conducted an epigenome-wide meta-analysis of associations between serum adiponectin (n=2791) and leptin (n=3661) and leukocyte DNA methylation at over 400,000 CpG sites across five European cohorts. The resulting methylation signatures were followed up using functional genomics, integrative analyses and causal inference methods.<

SUBMITTER: Sinke L 

PROVIDER: S-EPMC12686031 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature