Quantitative pupillometry as a sensitive tool for detecting tumor-related mass effect in the posterior fossa: a prospective feasibility study comparing metastatic versus skull base lesions.

ABSTRACT:

Objectives

Early and precise assessment of tumor-related mass effect is critical for surgical decision-making in patients with posterior fossa tumors, where even subtle elevations in intracranial pressure (ICP) may rapidly precipitate neurological decline. While quantitative pupillometry (QP) has demonstrated robust predictive capability for ICP-related deterioration in traumatic brain injury, its clinical utility for assessing neuro-oncological mass effects remains unexplored. This study aims to determine whether QP can reliably detect subtle neurological dysfunction related to mass effect in posterior fossa tumors, distinguishing specifically between metastatic and benign skull base lesions.

Methods

We prospectively analyzed 58 adults (mean age 55.6 ± 13.8 years, 60.3% fem

SUBMITTER: Grutza M 

PROVIDER: S-EPMC12686053 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature