Credibility Assessment of the Patient-Specific Modeling of the Aneurysmal Ascending Thoracic Aorta: Verification, Validation and Uncertainty Quantification.

ABSTRACT:

Purpose

Computational modeling holds promise in predicting patient-specific outcomes and guiding clinical decision-making. The patient-specific model forming the basis of a digital twin can be considered biomedical software, thereby necessitating trust in its predictive accuracy.

Methods

This study applies the ASME V&V40 framework to demonstrate the credibility of patient-specific models of aneurysmal thoracic ascending aorta (ATAA) biomechanics. A comprehensive verification, validation, and uncertainty quantification process was performed to evaluate the accuracy of the patient-specific ATAA model.

Results

After implementing the ASME V&V40 standard, the verification errors on the model inputs (i.e., material parameters and hemodynamic variables) resulted in relative

SUBMITTER: Scuoppo R 

PROVIDER: S-EPMC12686058 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature