Dracorhodin perchlorate alleviates sciatic nerve pain in CCI rats by modulating inflammation and promoting nerve repair.

ABSTRACT: This study analyzed protein sequencing from rat samples, categorized into a control group (Chronic Constriction Injury, CCI) and test (treated with dracorhodin perchlorate, DP), The purpose of this study was to identify key target proteins of DP in the treatment of sciatica and elucidate its underlying mechanisms. By comparing the differentially expressed proteins (DEPs) of the two groups at 1, 3, and 7 days post - treatment, it was revealed that DP consistently and significantly downregulated the expression of the Interleukin-6 (IL-6) and the cytokine-Induced neutrophil chemoattractant-3 (CINC-3), while significantly upregulating the expression of the neurotrophic factor ciliary neurotrophic factor (CNTF). Functional enrichment analysis indicated that these DEPs are primarily involved in

SUBMITTER: Wang X 

PROVIDER: S-EPMC12686064 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature